My name is Marc Laderriere. Born and raised
in France. I lived in Paso Robles, for the last 10 years. I work a lot. You know, less exercise, you
know, you paying less attention, and then, the one day you realize, hey, I’m a little
tired, what’s going on, you know? Also, we noticed, that I was sweating very,
very little, and I was very susceptible to heat, and I would basically get very, very
tired and like hit a wall. After multiple series of blood test through
the local doctors, we decided to go to Stanford to see what we could do. Mr. Laderriere was referred to us really because
of the fatigue, but also because his primary care physician noticed that his blood pressure
was changing quite a bit. When we examined him in the clinic, a few things were striking.
First, his pupillary reaction was not as we expected and his skin was unusually dry and
we happened to evaluate him here during a very hot day. So, he clearly had issues with
perspiration. And then, we measured his blood pressure again and we had him lay down for
about 10 minutes, stood him up and there was a persistent drop in his blood pressure. Dr. Jaradeh pretty much right away felt, it
probably was something that had to do with the autonomic nervous system. The autonomic nervous system is the part of
the nervous system that controls all the vital functions and the organs that are independent
of our own will. For instance, the reason why your heart beats is independent of your
will. The range of the autonomic disorders can be
fairly wide, as you might expect. The most common problems we find are first problems
in patients who cannot stay upright very long. Sometimes, patients present with unexplained
arrhythmias where the heart, you know, palpitates like crazy, the other presentation usually,
is patients who have major digestive issues. Then, heat tolerance can be a problem, because
if somebody cannot sweat, it’s really difficult for them to be out in the heat, they can develop
heat stroke fairly quickly. Testing these patients requires an integrated
approach, which is not available in many areas. During the first meeting, he asked, “Have
you ever been treated for Lyme Disease?” and I said, “Absolutely not.” So, we went through
that right away, and of course, we discovered right then that, I had Lyme Disease for probably
5 to 10 years. So, he, wanted me to be on antibiotics, to
eradicate the different markers of Lyme Disease. Now, I do not have any more Lyme Disease.
But it was clear, however, that I did have a autonomic nervous disorder of sorts. We believe that we found the cause and we’re
trying to address it. And then, we basically worked with him a regimen where we give him
medication that could help him with the sweating function, and in fact, he has noticed some
benefit from that. We also started giving him medication that, attenuate, or completely
eliminate, hopefully, the drop in his blood pressure, and we’ll watch and see how he does. He definitely has all the information and
he deals with, obviously, more difficult cases. I think we probably have stabilized his condition
at this point. I seems pretty confined, and in fact, couple of signs may be better. I’m fairly optimistic I think he will regain
more function in the next two years, I feel in good hands, there’s no doubt.

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11 thoughts on “Diagnosing and Treating Autonomic Disorder at Stanford – Marc Laderriere’s story

  1. The article on this was edited for some reason to remove the name of the infection. The original text on February 12th 2013 read:

    Laderriere, it turns out, had had Lyme disease without knowing it. Jaradeh treated Laderriere's Lyme disease with an extended course of antibiotics to make sure that he did not still have an active infection.

    But now it says:

    It turns out that Laderriere had had a bacterial disease without knowing it. Jaradeh treated Laderriere with an extended course of antibiotics to make sure that he did not still have an active infection.

    I'm highly suspect of the non-FDA approved tests being used to diagnose Lyme disease which may be giving people false-positives. However, I really want to know what is going on here. Perhaps the upcoming nano-trap antigen test will avoid confusion. Antigens seem the way to go for the future to detect infection. If Borrelia can go dormant in response to antibiotics like MRSA to persist then using these antigen tests should let us know when it re-activates or when it is there to begin with with more certainty than antibodies.

  2. I am glad that he got diagnosed and is manageable ……. I was born with my Dysautonomia's….. no cure or treatment for me….. gets worse with age….. I am completely home-bound………. but I do see that most people get their Dysautonomia's from Lyme Disease 

  3. There are so many other treatments that could have been used besides from conventional medications which often cause unwanted side effects.Traditional Chinese Medicine could be employed to treat the underlying causes of autonomic nervous system dysfunction and improve the autonomic balance of the body without unnecessary side effects. People often ignore holistic treatments and trust explicitly in mainstream pharmaceutical medications which may not treat the underlying causes of the condition.

  4. so where do you guys suggest to go for ans problems?? I have been to Dr jaradah tried florineg but made me feel worse :/

  5. Just saw a Stanford neurologist who basically told me previous diagnosis of POTS based upon testing in doctor office was not acceptable because it was Not a tilt table test. I have ME/CFS. Normally this doctor, like many neurologists she normally refuses to see CFS patients. But my primary called her. She told me all my problems are due to deconditioning. She refused to do tilt table test for me. She was contemptuous of the Stanford CFS clinic saying they recommend rest “…but we here at neurology believe in exercise.” I even have testing that shows my anaerobic threshold occurs at 78 bpm. Will not be going back to Stanford for anything. Doctors gaslighted me.

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